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Metabolic profiling of dietary polyphenols and methylxanthines in normal and malignant mammary tissues from breast cancer patients

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dc.contributor.authorÁvila-Gálvez, María Ángeles
dc.contributor.authorGarcía-Villalba, Rocío
dc.contributor.authorMartínez Díaz, Francisco
dc.contributor.authorOcaña-Castillo, Beatriz
dc.contributor.authorMonedero-Saiz, Tamara
dc.contributor.authorTorrecillas-Sánchez, Adela
dc.contributor.authorAbellán, Beatriz
dc.contributor.authorGonzález Sarrías, Antonio
dc.contributor.authorEspín, Juan Carlos
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.date.accessioned2024-12-12T11:50:52Z
dc.date.available2024-12-12T11:50:52Z
dc.date.issued2019-02-04
dc.description© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This document is the Published version of a Published Work that appeared in final form in Molecular Nutrition & Food Research. To access the final edited and published work see https://doi.org/ 10.1002/mnfr.201801239
dc.description.abstractScope: Dietary polyphenols may protect against breast cancer. However, it is unknown whether polyphenols reach human malignant breast tumors in molecular forms and(or) at concentrations likely to act against cancer. Methods and Results: Ninteen breast cancer patients consumed three capsules daily from biopsy-confirmed diagnosis to surgery (6 ± 2 days). The capsules contained pomegranate, orange, lemon, olive, cocoa, and grapeseed extracts plus resveratrol, providing 37 different phenolics (473.7 mg), theobromine and caffeine (19.7 mg). A total of 101 metabolites are identified in urine, 69 in plasma, 39 in normal (NT), and 33 in malignant (MT) tissues by UPLC-ESI-QTOF-MS. Eight control patients did not consume extracts. Phenolic-derived metabolites in MT and NT are mainly glucuronidated and(or) sulfated. Some representative metabolites detected in MT (median and range, pmol g−1) are urolithin-A-3-O-glucuronide (26.2; 3.2−66.5), 2,5-dihydroxybenzoic acid (40.2; 27.7−52.2), resveratrol-3-O-sulfate (86.4; 7.8−224.4), dihydroresveratrol-3-O-glucuronide (109.9; 10.3−229.4), and theobromine (715.0; 153.9−3,216). Metabolites, as detected in breast tissues, do not exert antiproliferative or estrogenic/antiestrogenic activities in MCF-7 breast cancer cells. Conclusion: This is the first study that describes the metabolic profiling of dietary phenolics and methylxanthines in MT and NT comprehensively. Although phase-II conjugation might hamper a direct anticancer activity, long-term tumor-senescent chemoprevention cannot be discarded.es
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dc.identifier.citationMol. Nutr. Food Res. 2019, 63, 1801239
dc.identifier.doihttps://doi.org/10.1002/mnfr.201801239
dc.identifier.issnPrint: 1613-4125
dc.identifier.issnElectronic: 1613-4133
dc.identifier.urihttp://hdl.handle.net/10201/147364
dc.languageenges
dc.publisherWiley, Wiley-VCH Verlag
dc.relationThe research reported in this article was supported by the Project 201770E081 from the Spanish National Research Council (CSIC, Spain). The products used in this study were kindly provided by Laboratorios Ad mira S.L. (Alcantarilla, Murcia, Spain). The authors are grateful to Dr. M. Madrigal and other surgeons from the Reina Sof´ıa Hospital (Murcia, Spain) for their contribution to the recruitment of patients and the revision of the manuscript. The authors also thank J.C. Esp´ın-Aguilar (IES Alc´antara, Alcantarilla, Murcia, Spain) for his technical support in some parts of the study.es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/mnfr.201801239
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.titleMetabolic profiling of dietary polyphenols and methylxanthines in normal and malignant mammary tissues from breast cancer patientses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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