Publication:
Role of angiogenesis on bone formation

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dc.contributor.authorPortal Núñez, Sergio
dc.contributor.authorLozano, Daniel
dc.contributor.authorEsbrit, Pedro
dc.date.accessioned2017-03-13T15:09:04Z
dc.date.available2017-03-13T15:09:04Z
dc.date.issued2012
dc.description.abstractAngiogenesis and bone formation are coupled during skeletal development and fracture healing. This relationship, although known for some time, has not been properly explored. Advances in the discovery of how angiogenesis is regulated in physiological processes like embryogenesis, endometrial regeneration and wound healing or in pathologies such as cancer have provided a deeper understanding of how angiogenic factors may interact with bone cells to improve bone formation and bone regeneration. The lack of oxygen (hypoxia) and the subsequent generation of angiogenic factors have been shown to be critical in the development of a regular skeleton and achieving successful bone regeneration and fracture healing. Given that vascular status is important for a proper bone homeostasis, defining the roles of osteoblasts, osteoclasts, endothelial cells and angiogenic factors and their interactions in bone is a key issue for the development of new strategies to manage bone pathologies and nonfused fractureses
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 5 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/52445
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAngiogenesises
dc.subjectOsteoblastes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleRole of angiogenesis on bone formationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 5 (2012)