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Impact of environmental exposures on exhaled breath and lung function: NELA Birth Cohort

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dc.contributor.authorJiménez Guerrero, Pedro
dc.contributor.authorSánchez-Solís de Querol, Manuel
dc.contributor.authorLozano Terol, Gema
dc.contributor.authorGallego Jara, Julia
dc.contributor.authorMartínez Vivancos, Adrián
dc.contributor.authorMorales Bartolomé, Eva
dc.contributor.authorGarcía-Marcos Álvarez, Luis Vicente
dc.contributor.authorDiego Puente, Teresa de
dc.contributor.authorNELA Study Group
dc.contributor.authorSola Martínez, Rosa Alba
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2025-11-11T12:15:44Z
dc.date.available2025-11-11T12:15:44Z
dc.date.copyright© 2025 The authors
dc.date.issued2025
dc.description.abstractIntroduction: Exposure to environmental factors (i.e. air pollution and second-hand tobacco smoke) have been associated with impaired lung function. However, the impact of environmental factors on lung health is usually evaluated separately and not with an exposomic framework. In this regard, breath analysis could be a noninvasive tool for biomonitoring of global human environmental exposure. Methods: Data come from 337 mother-child pairs from the Nutrition in Early Childhood Asthma (NELA) birth cohort. Levels of BTEX (benzene, toluene, ethylbenzene and xylenes) in exhaled breath from mothers and children at 3 months after birth were estimated using gas hromatography-mass spectrometry. Short-term residential exposures (breath sampling day and 15 days before breath sampling) to nitrogen dioxide, particulate matter (PM2.5) and ozone were determined by chemical dispersion/transport modelling. Forced vital capacity, forced expiratory volume in 0.5 s (FEV0.5) and forced expiratory flow at 75% of FVC and at 25%-75% of FVC were measured in infants according to the raised-volume rapid thoracoabdominal compression technique. Results: The results showed significant associations between short-term exposure to external agents and levels of benzene and toluene in exhaled breath. It was observed that exhaled levels of benzene and toluene were influenced by smoking status and outdoor air pollution in mothers, and by air pollution in infants (3 months of age). No significant relationship was observed between exposure to maternal tobacco smoking and/or short-term air pollution and lung function in healthy infants. However, there was a significant relationship between FEV0.5 and exhaled toluene in children. Discussion: These findings indicated a significant relationship between environmental exposures and exhaled levels of benzene and toluene, suggesting that breath analysis could be a helpful exposure biomonitoring tool.
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dc.identifier.citationERJ Open Res 2025;11:00597-2024
dc.identifier.doihttps://doi.org/10.1183/23120541.00597-2024
dc.identifier.issn2312-0541
dc.identifier.urihttp://hdl.handle.net/10201/172112
dc.languageeng
dc.publisherERS publications
dc.relationFinanciado por: project PID2021-122202OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, by the European Union, and the project PI21/00243 funded by Institute of Health Carlos III.
dc.relation.publisherversionhttps://publications.ersnet.org/content/erjor/11/1/00597-2024
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.odsObjetivo 3: Salud
dc.titleImpact of environmental exposures on exhaled breath and lung function: NELA Birth Cohort
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
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