Publication: Angiogenesis and expression of tenascin after transmural laser revascularization
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Date
1999
Authors
Gassler, N. ; Rastar, F. ; Hentz, M.W.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Transmyocardial revascularization (TMR)
with CO2-laser equipment is an alternative approach in
the treatment of patients with severe ischemic cardiac
disease. Several studies concerning morphological
features after TMR document a strong transmyocardial
injury, but little is known about wound healing in laserinduced
alterations of the cardiac skeleton and their
putative role for angiogenesis and endothelialization.
The present study was conducted to establish a useful
immunohistochemical marker for detection of these
laser-induced injuries and to analyze starting points of
angiogenesis in human myocardium after TMR. Our
data show that tenascin labeling is a useful immunohistochemical
approach to detect laser-alterated
segments of the cardiac skeleton as well as laser-induced
fibrosis. Starting points of the angiogenetic process are
seen throughout the margins of laser-induced lesions,
where myocardial capillaries are found. Disrupted
vessels located within laser-alterated connective tissue
septa are not major starting points for endothelialization
of laser-induced lesions and for capillary sprouts. In
comparison to laser-induced fibrosis, induction and
promotion of angiogenesis by laser radiation is weak.
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