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CD28 and KIR2D receptors as sensors of the immune status in heart and liver transplantation

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dc.contributor.authorBlanco García, R. M.
dc.contributor.authorLópez Álvarez, María R.
dc.contributor.authorGarrido, I. P.
dc.contributor.authorSalgado Cecilia, G.
dc.contributor.authorCampillo, José Antonio
dc.contributor.authorBolarín, José Miguel
dc.contributor.authorMuro, Manuel
dc.contributor.authorGarcía Alonso, A.M.
dc.contributor.authorMartínez Sánchez, María V.
dc.contributor.authorPeña Moral, J.M. de la
dc.contributor.authorPascual Figal, Domingo A.
dc.contributor.authorÁlvarez López, María Rocio
dc.contributor.authorMiras, M.
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-12T08:09:48Z
dc.date.available2024-07-12T08:09:48Z
dc.date.issued2011-06-22
dc.description© 2011 American Society for Histocompatibility and Immunogenetics. This document is the Published versión of a published Work that appeared in final form in Human Immunology. To access the final edited and published work see https://doi.org/10.1016/j.humimm.2011.06.004
dc.description.abstractViral infections and cellular acute rejection (AR) condition immunosuppressive therapy and compromise the evolution of allografts. Immune monitoring can be useful for ascertaining rejection and for differentiating allo-reaction from activation induced by infections. This work analyzes the usefulness of monitoring the expression of CD28 and KIR2D receptors in peripheral blood T lymphocytes by flow cytometry, to ascertain the immune response in heart and liver transplant recipients. In both types of transplant, the up-regulation of CD28 in CD4+ lymphocytes in the periods of greatest AR frequency indicates an effective allo-response, whereas the post-transplantation emergence of circulating CD8+CD28− and CD8+CD28−KIR2D+ T cells correlates with better early clinical results. Cytomegalovirus (CMV) infection, but not hepatitis C virus (HCV) or other infections, abrogated both CD28 up-regulation and CD8+CD28−KIR2D+ T-cell expansion. Our results show that monitoring the expression of CD28 and KIR2D receptors on T lymphocytes might be considered as sensors of the immune status of heart and liver recipients.es
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dc.format.extent8es
dc.identifier.citationHuman Immunology 72 (2011) 841-848
dc.identifier.doihttps://doi.org/10.1016/j.humimm.2011.06.004
dc.identifier.issnPrint: 0198-8859
dc.identifier.urihttp://hdl.handle.net/10201/143047
dc.languageenges
dc.publisherElsevier
dc.relationThis work was supported by SénecaFundation, CajaMurcia and Instituto de Salud Carlos III (ISCiii, 07/1224), Ministerio de Ciencia e Innovación, Spain. CIBERehd is funded by ISCiii, Centro de Investigación Biomédica en Red de Enfermedades HepÂticas y Digestivas, CIBEREHD. Blanco-García and López-Alvarez were funded by Fundación Séneca and CIBERehdes
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0198885911001480?via%3Dihub
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHeart transplantationes
dc.subjectLiver transplantationes
dc.subjectCD28es
dc.subjectKIR2Des
dc.subjectCMVes
dc.titleCD28 and KIR2D receptors as sensors of the immune status in heart and liver transplantationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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