Publication:
Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels

Simple item page
dc.contributor.authorGómez-Gil, E.
dc.contributor.authorMartín-García, R.
dc.contributor.authorVicente-Soler, J.
dc.contributor.authorFranco, A.
dc.contributor.authorVázquez-Marín, B.
dc.contributor.authorPrieto-Ruiz, F.
dc.contributor.authorSoto, T.
dc.contributor.authorPérez, P.
dc.contributor.authorMadrid, M.
dc.contributor.authorCansado Vizoso, José
dc.contributor.departmentGenética y Microbiología
dc.date.accessioned2021-03-16T13:16:00Z
dc.date.available2021-03-16T13:16:00Z
dc.date.created2020
dc.date.issued2020-09-11
dc.description.abstractCytokinesis, which enables the physical separation of daughter cells once mitosis has been completed, is executed in fungal and animal cells by a contractile actin- and myosin-based ring (CAR). In the fission yeast Schizosaccharomyces pombe, the formin For3 nucleates actin cables and also co-operates for CAR assembly during cytokinesis. Mitogen-activated protein kinases (MAPKs) regulate essential adaptive responses in eukaryotic organisms to environmental changes. We show that the stress-activated protein kinase pathway (SAPK) and its effector, MAPK Sty1, downregulates CAR assembly in S. pombe when its integrity becomes compromised during cytoskeletal damage and stress by reducing For3 levels. Accurate control of For3 levels by the SAPK pathway may thus represent a novel regulatory mechanism of cytokinesis outcome in response to environmental cues. Conversely, SAPK signaling favors CAR assembly and integrity in its close relative Schizosaccharomyces japonicus, revealing a remarkable evolutionary divergence of this response within the fission yeast clade.es
dc.formatapplication/pdfes
dc.format.extente57951es
dc.identifier.citationElife. 2020, 9:e57951
dc.identifier.doi10.7554/eLife.57951
dc.identifier.issn2050-084x
dc.identifier.urihttp://hdl.handle.net/10201/105007
dc.languageenges
dc.publisherELIFE SCIENCES PUBLICATIONS LTDes
dc.relationTítulo: Regulación por MAP quinasas del citoesqueleto de actina y la polaridad celular. Ministerio de Economía y Competitividad. Plan Nacional Convocatoria de Excelencia 2017. BFU2017-82423-P. Título: MAP quinasas y sensibilidad al quórum como reguladores de respuestas adaptativas frente al estrés, la diferenciación y el dimorfismo en levaduras con fisión. Fundación Séneca. Ayudas a la realización de proyectos para el desarrollo de la investigación científica y técnica por grupos competitivos 2018. 20856/PI/18.es
dc.relation.isreplacedbyhttps://elifesciences.org/articles/57951es
dc.relation.publisherversionhttps://elifesciences.org/articles/57951es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectS. pombees
dc.subjectActomyosin ringes
dc.subjectCell biologyes
dc.subjectFormines
dc.subjectMAP kinasees
dc.subjectMicrobiologyes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::579 - Microbiologíaes
dc.titleStress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levelses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
eLife_Gomez_Gil_et_al_2020.pdf
Size:
31.22 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos