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The angiotensin converting enzyme 2 (ACE2) system in the brain: possible involvement in Neuro-Covid

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dc.contributor.authorvon Bohlen und Halbach, Oliver
dc.date.accessioned2023-01-31T09:50:43Z
dc.date.available2023-01-31T09:50:43Z
dc.date.issued2021
dc.description.abstractThe brain has its own intrinsic reninangiotensin system (RAS) with all its components present in the central nervous system (CNS). Recent data demonstrate that also the main components of the angiotensin concerting enzyme 2 (ACE2) system (at least ACE2 itself, as well as the biologically active angiotensin (1-7) and its cognate receptor Mas) are expressed in the brain. Aside from these members, alamadine and MrgD are discussed as further members that have neuro-active roles in the CNS. Little is known about the possible functions of MrgD within the brain. Concerning angiotensin (1-7) acting through the Mas receptor, data were accumulating that this system is involved in numerous processes contributing to neuronal plasticity and even learning and memory. Malfunctions in the brain ACE2 system are associated with disturbances in neuronal plasticity. Since SARS-CoV-2 has a high affinity towards ACE2, Neuro-Covid may directly or indirectly depend on a disturbed balance in the ACE2 derived angiotensin system in the brain. Since the ACE2 system in the brain is far from being understood, a deeper understanding of e.g. the angiotensin (1-7) / Mas system is needed, especially with regard to the roles of angiotensin (1-7) in neuronal plasticity.es
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dc.format.extent7es
dc.identifier.citationHistology and Histopathology Vol. 36, nº11 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-356
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127984
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectACE2es
dc.subjectAngiotensin (1-7)es
dc.subjectDistributiones
dc.subjectMases
dc.subjectMrgDes
dc.subjectNeuronal plasticityes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe angiotensin converting enzyme 2 (ACE2) system in the brain: possible involvement in Neuro-Covides
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36,nº11 (2021)