Publication: Ontogeny of the antigen-reactive lymph follicle-forming capacity of the popliteal lymph node in neonatal mice
Authors
Hiramoto, M. ; Aizawa, S. ; Horie, K. ; Nagata, H. ; Hoshi, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The ontogenetic development of the reactive
lymph follicle-forming capacity of the popliteal lymph
node was investigated immunohistochemically in young
mice which had received a single injection of
hemocyanin (KLH) in a rear footpad at a predetermined
age (between 1 and 21 days). The mice were sacrificed
at various intervals after injection. In non-stimulated
young mice, primary lymph follicles first appeared in the
popliteal node at 11 days of age. When KLH was given
to 7-day-old or older mice, each draining popliteal node
showed a marked increase in B lymphocytes in the
extrafollicular zone 3 days after injection and produced a
number of ‘new’ lymph follicles outside the pre-existing
follicles over the next few days. In mice injected at 2-4
days of age, these nodes showed an increase in B
lymphocytes in the outer cortex and had produced
several lymph follicles by 8 days of age. The number of
lymph follicles produced by each node tended to
increase in line with age at injection. These results
indicate that neonatal popliteal nodes become able to
produce lymph follicles in response to exogenous
antigens some time before ontogenetically developing
follicles appear. The formation of new lymph follicles
observed in draining popliteal nodes after KLH injection at an early postnatal age is discussed in relation to the
ontogenetic development of stromal cells (precursors of
follicular dendritic cells) that are capable of interacting
with B lymphocytes and the extent of B lymphocyte
influx into the node induced by KLH stimulation.
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