Publication: Surface morphology and ultrastructure of normal
and cyclic hematopoietic canine bone marrow
in long-term liquid cultures
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Date
1989
Authors
Al-Lebban, Z.S. ; Lange, R.D. ; Jones, J.B. ; Lothrop, Jr.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Long-term liquid cultures of normal and
cyclic hematopoietic (CH) dog bone marrow produce
committed granulocyte-macrophage progenitor cells
(CFU-GM) and differentiated granulocytes for severa1
weeks. Analysis of in situ fixed cultures or of cells
harvested from the culture supernatants revealed that
the cells had ultrastructure and surface morphology
characteristic of immature and mature rnyeloid cells. The
surface rnorphologies of adherent cells from both normal
and CH dogs were similar. The characteristic
abnormalities previously reported in neutrophils
obtained from CH dogs were not observed in neutrophils
obtained from long-term marrow cultures of CH dogs.
These results indicate that the cellular abnormalities in
the neutrophils of CH dogs may be secondary
manifestations of the disease and are not inherent to the
pathogenesis of the hematopoietic cells.
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Citation
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