Publication: Visual pathology in animal prion diseases
Authors
Ye, Xuemin
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Prion diseases, also known as the
transmissible spongiform encephalopathies (TSEs), are a
group of slowly developing neurodegenerations
occurring in human and animals. Prion diseases can be
transferred between animals, humans, from humans to
animals, and from animals to humans. As a result, the
central nervous system is attacked, resulting in microglia
activation, astrocytosis, prion plaque deposition, and
neuronal degeneration. Prion also targets on the eye and
brain visual system. In scrapie-infected sheep, chronic
wasting disease (CWD)-infected mule deer, and
experimental animals infected with scrapie,
transmissible mink encephalopathy (TME), and
Creutzfeldt-Jakob disease (CJD), damage has been
found in the outer and inner nuclear layers of the retina,
brain stem, optic nerve, optic tract, optic radiation and
visual cortex. This article reviews the prion agent and
infectivity in the eye and brain visual system, and the
visual and oculomotor pathology in animal prion
diseases. Effects of PrP genotypes and PrPSc types on
visual and oculomotor disorders will be discussed.
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Citation
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