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Mutation stability in primary and metastatic melanoma: what we know and what we don’t

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dc.contributor.authorVarada, Sowmya
dc.contributor.authorMahalingam, Meera
dc.date.accessioned2020-09-21T11:11:29Z
dc.date.available2020-09-21T11:11:29Z
dc.date.issued2015
dc.description.abstractDespite the efficacy and success of targeted therapies, a significant number of patients with melanoma exhibit either intrinsic or acquired resistance to these drugs. Numerous mechanisms for the development of resistance have been postulated, but the precise reason for this is not known. In this review, we examine the incidence of mutations in select genes (BRAF, NRAS, C-KIT, and GNAQ) known to occur in melanoma, specifically in primary tumors and their paired metastases, to understand the significance of intratumoral heterogeneity by assessing how changes in mutation status alters the process of metastatic spread. Our data revealed a small yet consistent degree of discordance of mutations in the MAPK pathway commonly occurring in melanoma indicating that failed targeted therapy may be a consequence of this.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, vol.30, nº 7, (2015)
dc.identifier.doi10.14670/HH-11-584
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96222
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMelanomaes
dc.subjectMutationses
dc.subjectStabilityes
dc.subjectBRAFes
dc.subjectNRASes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMutation stability in primary and metastatic melanoma: what we know and what we don’tes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº7 (2015)