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Spatial distribution of human asymptomatic Leishmania infantum infection in southeast Spain: a study of environmental, demographic and social risk factors

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dc.contributor.authorPérez Cutillas, Pedro
dc.contributor.authorGoyena Salgado, Elena
dc.contributor.authorChitimia Dobler, Lidia
dc.contributor.authorRúa Tarín, Pilar de la
dc.contributor.authorBernal Gambín, Luis Jesús
dc.contributor.authorFisa, Roser
dc.contributor.authorRiera, Cristina Ferri
dc.contributor.authorIborra Bendicho, Maria Asunción
dc.contributor.authorMurcia, Laura
dc.contributor.authorSegovia Hernández, Manuel
dc.contributor.authorBerriatua Fernández de Larrea, Eduardo
dc.contributor.departmentAnatomía y Anatomía Patológica Comparada
dc.contributor.otherFacultades de la UMU::Facultad de Veterinaria
dc.date.accessioned2026-02-02T11:45:47Z
dc.date.available2026-02-02T11:45:47Z
dc.date.copyright© 2015 Elsevier B.V.
dc.date.issued2015-03-20
dc.description.abstractRecent PCR studies indicate that asymptomatic L. infantum infection is common in people in southern Europe. Understanding its spatial distribution is a requisite to evaluate the public health implications and to design disease control schemes. We investigated infection in blood samples from 657 donors in southeast Spain using PCR and antibody ELISA. They came from 19 blood centers and were interviewed about their residence, occupation, dog ownership and Leishmaniosis awareness. The percentage of PCR and ELISA positives were 8% (49/618) and 2% (13/657). Donor's residences were spatially clustered around blood donning centers and PCR prevalence was 18% in rural municipalities with 20–1330 inhabitants, 12% in those with 1467–5088 inhabitants and 3% in larger communities, and was associated with dog ownership (p < 0.05). Further analysis of data from rural donors indicated that PCR status was strongly related to the climate, altitude and soil type in the donor's residence area and not to other demographic or sociologic variables. Mixed logistic regression analysis predicted PCR prevalence to be greatest in the 200–300 m altitude range with a mean spring–summer (time of highest vector activity) temperature of 18.4–19.0 °C. A temperature and altitude risk map was generated that will provide the basis for elaborating evidence-based vector surveillance studies.
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dc.format.extent8
dc.identifier.citationActa Tropica, 2015, Vol. 146, pp. 127-134
dc.identifier.doihttps://doi.org/10.1016/j.actatropica.2015.03.017
dc.identifier.issn0001-706X
dc.identifier.urihttp://hdl.handle.net/10201/198129
dc.languageeng
dc.publisherElsevier
dc.relationThis study was funded by the Fundación Séneca de la Región de Murcia (Pr. Ref: 08714/PI/08), the Spanish Ministry of Science and Innovation (Pr. Ref: AGL2013-46981-R) and the Instituto de Salud Carlos III within the Network of Tropical Diseases Research (RICET RD12/0018/0018). Authors of this paper are presently members and receive support from COST Action TD1303 (European Network for Neglected Vectors and Vector-borne infections).
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0001706X15000765
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectInfection
dc.subjectEpidemiology
dc.subjectSpain
dc.subjectBlood donors
dc.subjectSpatial distributiona
dc.subjectAsymptomatic Leishmania infantum
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleSpatial distribution of human asymptomatic Leishmania infantum infection in southeast Spain: a study of environmental, demographic and social risk factors
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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