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GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression

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dc.contributor.authorPinheiro, Céline
dc.contributor.authorSousa, Bárbara
dc.contributor.authorAlbergaria, André
dc.contributor.authorParedes, Joana
dc.contributor.authorDufloth, Rozany
dc.contributor.authorVieira, Daniella
dc.contributor.authorSchmitt, Fernando
dc.contributor.authorBaltazar, Fátima
dc.date.accessioned2016-04-29T14:04:31Z
dc.date.available2016-04-29T14:04:31Z
dc.date.issued2011
dc.description.abstractThe goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in breast cancer. The clinico-pathological value of GLUT1 and CAIX was also evaluated. For that, we analysed the immunohistochemical expression of GLUT1 and CAIX, in a large series of invasive breast carcinoma samples (n=124), previously characterized for MCT1, MCT4 and CD147 expression. GLUT1 expression was found in 46% of the cases (57/124), while CAIX was found in 18% of the cases (22/122). Importantly, both MCT1 and CD147, but not MCT4, were associated with GLUT1 and CAIX expression. Also, GLUT1 and CAIX correlated with each other. Concerning the clinicopathological values, GLUT1 was associated with high grade tumours, basal-like subtype, absence of progesterone receptor, presence of vimentin and high proliferative index as measured by Ki-67. Additionally, CAIX was associated with large tumour size, high histological grade, basal-like subtype, absence of estrogen and progesterone receptors and presence of basal cytokeratins and vimentin expression. Finally, patients with CAIX positive tumours had a significantly shorter disease-free survival. The association between MCT1 and both GLUT1 and CAIX may result from hypoxia-mediated metabolic adaptations, which confer a glycolytic, acid-resistant and more aggressive phenotype to cancer cells.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/49443
dc.languageenges
dc.publisherF. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología.es
dc.relation.ispartofHistology and histopathology, Vol. 26, nº10 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectGLUT1es
dc.subjectCAIXes
dc.subjectBreast carcinomaes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleGLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpressiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26,nº10 (2011)