Publication: In vitro effects of hormones and
autacoids on the activity of acid phosphatase
in the lysates of endotoxin-activated rat peritoneal
and bronchoalveolar macrophages
Authors
Kondomerkos, D.J. ; Kalamidas, Stefanos ; Kotoulas, Othon B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Peritoneal and bronchoalveolar macrophages
activated in vitro by endotoxin, exhibit alterations in the
acid phosphatase activity of cell lysates when certain
hormones or autacoids are present in the culture
medium. They also show morphological changes
concerning general appearance and acid phosphatase
cytochemistry. Certain agents known to increase the
intracellular levels of cyclic AMP, such as dopamine and
prostaglandin E2, decreased this enzyme activity in the
lysates of peritoneal macrophages. Adrenalin had no
effect on this activity at 14 hours, but was found to
increase the activity in the culture medium at the initial
hours of incubation. Glucagon decreased whereas insulin
increased acid phosphatase activity in bronchoalveolar
macrophages. Serotonin or histamine, known to activate
phospholipase C, increased this activity in peritoneal or
bronchoalveolar macrophages. The results of this study,
taken together with previously published data
(Kondomerkos et al., 2003), suggest that hormones and
autacoids may control certain parameters of macrophage
activation including acid phosphatase activity.
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Citation
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