Molecular fingerprint of gilthead seabream physiology in response to pollutant mixtures in the wild

Beauvieux, Anaïs; Fromentin, Jean-Marc; Romero, Diego; Couffin, Nathan; Brown, Adrien; Metral, Luisa; Bourjea, Jérôme; Bertile, Fabrice; Schull, Quentin

Publication:
Molecular fingerprint of gilthead seabream physiology in response to pollutant mixtures in the wild

dc.contributor.author	Beauvieux, Anaïs
dc.contributor.author	Fromentin, Jean-Marc
dc.contributor.author	Romero, Diego
dc.contributor.author	Couffin, Nathan
dc.contributor.author	Brown, Adrien
dc.contributor.author	Metral, Luisa
dc.contributor.author	Bourjea, Jérôme
dc.contributor.author	Bertile, Fabrice
dc.contributor.author	Schull, Quentin
dc.contributor.department	Ciencias Sociosanitarias
dc.date.accessioned	2024-03-14T08:43:31Z
dc.date.available	2024-03-14T08:43:31Z
dc.date.created	2023-10-30
dc.description	©2023 Elsevier. This document is the Published version of a Published Work that appeared in final form in Environmental Pollution. To access the final edited and published work see https://doi.org/10.1016/j.envpol.2023.122789	es
dc.description.abstract	The increase in trace element concentrations in the aquatic environment due to anthropogenic activities, urges the need for their monitoring and potential toxicity, persistence, bioaccumulation, and biomagniﬁcation at different trophic levels. Gilthead seabream is a species of commercial importance in the Mediterranean Sea, both for the aquaculture and ﬁsheries sectors, however very little is known about their trace element contamination accumulation and the resulting effect on their health status. In the present study, 135 juveniles were collected from seven coastal lagoons known to be essential nursery areas for this species. We measured seventeen different inorganic contaminants at the individual level in ﬁsh muscle (namely Al, As, Be, Bi, Cd, Cr, Cu, Hg, Li, Ni, Pb, Rb, Sb, Sr, Ti, Tl and Zn). Our results revealed the accumulation of multiple trace elements in individuals and distinct contamination signatures between lagoons which might lead to contrasted quality as nurseries for juveniles of numerous ecologically and economically relevant ﬁsh species in addition to seabreams. We further evaluated the potential adverse effect of these complex contamination mixtures on the liver (the main organ implicated in the metabolism of xenobiotics) and red muscle (a highly metabolic organ) using a proteomic approach. Alterations in cellular organization pathways and protein transport were detected in both tissues (albeit they were not similarly regulated). Chromosome organization and telomere maintenance in the liver appeared to be affected by contaminant mixture which could increase mortality, age-related disease risk and shorter lifetime expectancy for these juveniles. Red muscle proteome also demonstrated an upregulation of pathways involved in metabolism in response to contamination which raises the issue of potential energy allocation trade-offs between the organisms’ main functions such as reproduction and growth. This study provides new insights into the cellular and mo-lecular responses of seabreams to environmental pollution and proposed biomarkers of health effects of trace elements that could serve as a starting point for larger-scale biomonitoring programs.	es
dc.format	application/pdf	es
dc.format.extent	13	es
dc.identifier.citation	Environmental Pollution, Vol. 340, Part 2, 2024, 122789
dc.identifier.doi	https://doi.org/10.1016/j.envpol.2023.122789
dc.identifier.issn	Print: 0269-7491
dc.identifier.issn	Electronic: 1873-6424
dc.identifier.uri	http://hdl.handle.net/10201/140190
dc.language	eng	es
dc.publisher	Elsevier	es
dc.relation	This work is part of the project ICIPOP granted by the “Agence Francaise de Developpement” (AFD). A. B. had a PhD grant from the University of Montpellier – GAIA doctoral school.	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0269749123017918?via%3Dihub	es
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	Shotgun proteomic	es
dc.subject	Ecotoxicology	es
dc.subject	Sparus aurata	es
dc.subject	Fish health	es
dc.subject	Lagoon	es
dc.subject	Cocktail effect	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::59 - Zoología	es
dc.title	Molecular fingerprint of gilthead seabream physiology in response to pollutant mixtures in the wild	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es