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Quorum sensing and stress-activated MAPK signaling repress yeast to hypha transition in the fission yeast Schizosaccharomyces japonicus

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dc.contributor.authorGómez-Gil, Elisa
dc.contributor.authorFranco Sánchez, Alejandro
dc.contributor.authorMadrid, Marisa
dc.contributor.authorVázquea-Marín, Beatriz
dc.contributor.authorGacto, Mariano
dc.contributor.authorFenández-Breis, Jesualdo
dc.contributor.authorVicente-Soler, Jero
dc.contributor.authorSoto, Teresa
dc.contributor.authorCansado Vizoso, José
dc.contributor.departmentGenética y Microbiología
dc.date.accessioned2021-03-16T15:23:22Z
dc.date.available2021-03-16T15:23:22Z
dc.date.issued2019-05
dc.description.abstractQuorum sensing (QS), a mechanism of microbial communication dependent on cell density, governs developmental decisions in many bacteria and in some pathogenic and non-pathogenic fungi including yeasts. In these simple eukaryotes this response is mediated by the release into the growth medium of quorum-sensing molecules (QSMs) whose concentration increases proportionally to the population density. To date the occurrence of QS is restricted to a few yeast species. We show that a QS mediated by the aromatic alcohols phenylethanol and tryptophol represses the dimorphic yeast to hypha differentiation in the fission yeast S. japonicus in response to an increased population density. In addition, the stress activated MAPK pathway (SAPK), which controls cell cycle progression and adaptation to environmental changes in this organism, constitutively represses yeast to hypha differentiation both at transcriptional and post-translational levels. Moreover, deletion of its main effectors Sty1 MAPK and Atf1 transcription factor partially suppressed the QS-dependent block of hyphal development under inducing conditions. RNAseq analysis showed that the expression of nrg1+, which encodes a putative ortholog of the transcription factor Nrg1 that represses yeast to hypha dimorphism in C. albicans, is downregulated both by QS and the SAPK pathway. Remarkably, Nrg1 may act in S. japonicus as an activator of hyphal differentiation instead of being a repressor. S. japonicus emerges as an attractive and amenable model organism to explore the QS mechanisms that regulate cellular differentiation in fungi.es
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dc.format.extent72es
dc.identifier.citationPLoS Genetics, 2019, 15(5): e1008192
dc.identifier.doi10.1371/journal.pgen.1008192
dc.identifier.urihttp://hdl.handle.net/10201/105011
dc.languageenges
dc.publisherPublic Library of Sciencees
dc.relationThis work was supported by grants from the Ministerio de Economía y Competitividad (BFU2017-82423-P), and Fundación Séneca-Región de Murcia (20856/PI/18), Spain, both awarded to JC.es
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pgen.1008192es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectQuorum sensinges
dc.subjectSchizosaccharomyces japonicuses
dc.subjectMAPK signalinges
dc.titleQuorum sensing and stress-activated MAPK signaling repress yeast to hypha transition in the fission yeast Schizosaccharomyces japonicuses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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