Publication: Temporal and quantitative analysis of expression of metalloproteinases MMPs and their endogenous inhibitors in atherosclerotic lesions
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Date
2008
Authors
Yu, Ying ; Koike, Tomonari ; Kitajima, Shuji ; Liu, Enqi ; Morimoto, Masatoshi ; Shiomi, Masashi ; Hatakeyama, Kinta ; Asada, Yujiro ; Wang, Ke-Yong ; Sasaguri, Yasuyuki ; Watanabe, Teruo
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Publisher
Murcia : F. Hernández
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Fan, Jianglin
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Matrix metalloproteinases (MMPs) play an
important role in the pathogenesis of vascular diseases,
such as atherosclerosis, plaque rupture and aneurysms.
Although several MMPs have been demonstrated in the
lesions of atherosclerosis, their expression profiles
during the initiation and progression of lesions have not
been fully determined. We hypothesized that the
expression of various MMPs, along with their
endogenous inhibitors, may be differentially regulated
dependent upon the lesion progression. Therefore, we
made a temporal and quantitative analysis of the mRNA
and protein expression of MMPs and tissue inhibitors of
metalloproteinases expressed in the different stages of
atherosclerotic lesions of rabbits and humans. We found
that MMP-1, MMP-12 and MMP-13 expression was
nearly absent in the normal arterial wall, but was
remarkably increased with lesion progression.
Furthermore, the expression of these MMPs in the
lesions was closely associated with intimal macrophages
and monocyte chemoattractant protein-1 expression,
suggesting that the intimal macrophages are the major
source of production of these MMPs. MMP-3 and MT1-
MMP were also significantly upregulated in the earlystage
lesions and fatty streaks compared to the normal
aortas of rabbits. Our results indicate that MMP-1, -12,
and -13 derived from intimal macrophages may play a pivotal role in both lesion initiation and progression, and
therefore are potential therapeutic targets for the
treatment of plaque rupture and aneurysm formation.
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