Publication: Tissutal imaging by nuclear magnetic resonance
Authors
Sbarbati, A. ; Osculati, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present work reviews the main
applications of nuclear magnetic resonance (NMR)-
technology and, in particular, of magnetic resonance
imaging (MRI) to tissutal analysis. To date, MRI
represents a precise and reliable tool to investigate
morphology and functional modification of tissues in
vivo, providing information consistent with histology.
MRI has numerous advantages over conventional
techniques: it is harmless to tissues; volume
measurements in vivo could be useful for morphometric
studies; the sarne tissue can be examined severa1 times
(e.g. at different ages); several organs can be examined
at the same time; serial sections of relevant structures
can be obtained in al1 planes, thereby allowing detailed
reconstruction of the three-dimensional configuration of
organs; motion within a tissue can be detected; and
subsequent histological and ultrastructural studies of the
tissue are possible. The main drawback (besides the cost
of the basic instrumentation) is that resolution is
relatively low in comparison with light microscopy.
Finally, the analysis of the results is difficult, needing
interdisciplinary competence, and MRI methods of
tissutal analysis are not yet well standardized. Therefore,
in our opinion, MRI is an interesting tool,
complementary to other histological techniques, and it
cannot be ignored by microscopists. However, in vivo
MRI data must be evaluated with caution and
histological controls are always required.
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