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Defective expression of the peroxisome regulators PPARα receptors and lysogenesis with increased cellular senescence in the venous wall of chronic venous disorder

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dc.contributor.authorOrtega, Miguel A
dc.contributor.authorFraile-Martínez, Oscar
dc.contributor.authorPekarek, Leonel
dc.contributor.authorAlvarez-Mon, Miguel A.
dc.contributor.authorAsúnsolo, Ángel
dc.contributor.authorSanchez-Trujillo, Lara
dc.contributor.authorCoca, Santiago
dc.contributor.authorBuján, Julia
dc.contributor.authorÁlvarez-Mon, Melchor
dc.contributor.authorGarcíaHonduvilla, Natalio
dc.contributor.authorSain, Felipe
dc.date.accessioned2023-01-12T10:23:13Z
dc.date.available2023-01-12T10:23:13Z
dc.date.issued2021
dc.description.abstractThe pathogenesis of chronic venous disorder (CVeD) remains partially understood. A marked wall remodeling has been shown with potential accelerated tissue senescence. We have investigated the expression of peroxisome proliferator-activated receptor (PPAR) isoforms transcription factor EB (TFEB) as regulatory molecules of cellular homeostasis and makers of peroxisomal and lysosomal biogenesis. We have also quantified p16 expression as a cellular senescence marker. In specimens of maior safena vein from 35 CVeD and 27 healthy venous controls (HV), we studied the expression of PPAR-α, PPAR-β/δ, PPAR-γ, TFEB and p16 by RT-qPCR and immunohistochemical techniques. We have demonstrated a reduced gene and protein expression of the PPAR-α and PPAR-β/δ isoform as well as that of TFEB in the venous wall of CVeD patients, suggesting an altered peroxisomal and lysosomal biogenesis associated with an increased cellular senescence shown by increased p16 expressiones
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dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 36, nº5 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-322
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127205
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChronic venous disorderes
dc.subjectCVeDes
dc.subjectVascular homeostasises
dc.subjectPPARes
dc.subjectTFEBes
dc.subjectSenescencees
dc.subjectp16es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleDefective expression of the peroxisome regulators PPARα receptors and lysogenesis with increased cellular senescence in the venous wall of chronic venous disorder
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36, nº5 (2021)