Verapamil parameter- and dose-dependently impairs memory consolidation in open field habituation task in rats

Giménez de Béjar, Verónica; Caballero Bleda, María; Popovic, Natalija; Popovic Popovic, Miroljub

Publication:
Verapamil parameter- and dose-dependently impairs memory consolidation in open field habituation task in rats

dc.contributor.author	Giménez de Béjar, Verónica
dc.contributor.author	Caballero Bleda, María
dc.contributor.author	Popovic, Natalija
dc.contributor.author	Popovic Popovic, Miroljub
dc.contributor.department	Anatomía Humana y Psicobiología
dc.date.accessioned	2024-06-18T10:36:06Z
dc.date.available	2024-06-18T10:36:06Z
dc.date.issued	2017-01-10
dc.description	© 2017 Popovic, Giménez de Béjar, Caballero-Bleda and Popovic. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Frontiers in Pharmacology. To access the final edited and published work see https://doi.org/10.3389/fphar.2016.00539
dc.description.abstract	The purpose of the present study was to examine the effects of the phenylalkylamine class of the L-type voltage-dependent calcium channel antagonist, verapamil (1.0, 2.5, 5.0, or 10 mg/kg i.p.), administered immediately after the acquisition task, on memory consolidation of the open field habituation task, in male Wistar rats. On the 48 h retested trial, all tested parameters (ambulation in the side wall and in the central areas, number of rearing, time spent grooming and defecation rate) significantly decreased in the saline treated animals. A significant decrease of rearing was observed in all verapamil treated groups. On the retention day, the ambulation in the side wall and central areas significantly decreased in the animals treated with 1 mg/kg and 10 mg/kg of verapamil, while the time spent grooming and the defecation rate significantly decreased only in the group treated with 1 mg/kg of verapamil. According to the change ratio scores that correct the individual behavioral baseline differences during initial and final sessions, habituation deficit was found in animals treated with verapamil as follows: ambulation along the side wall area (1, 2.5, and 5 mg/kg), number of rearing (all used dose) and time spent grooming (2.5, 5, and 10 mg/kg). In conclusion, the present data suggest that the post-training administration of verapamil, parameter- and dose-dependently, impairs the habituation to a novel environment.	es
dc.format	application/pdf	es
dc.format.extent	6	es
dc.identifier.citation	Front Pharmacol. January 2017 7:539
dc.identifier.doi	https://doi.org/10.3389/fphar.2016.00539
dc.identifier.issn	Electronic: 1663-9812
dc.identifier.uri	http://hdl.handle.net/10201/142400
dc.language	eng	es
dc.publisher	Frontiers Media	es
dc.relation	Funding for this study was provided by the Health Council of Murcia Region, Spain (MC) and the Spanish Ministry of Economy and Competitiveness (BFU2014-57516-P; LPL, JLF). The funding source had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.	es
dc.relation.publisherversion	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2016.00539/full	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Habituation	es
dc.subject	Memory consolidation	es
dc.subject	Open field	es
dc.subject	Verapamil	es
dc.subject	Rat	es
dc.subject.other	CDU::6 - Ciencias aplicadas	es
dc.title	Verapamil parameter- and dose-dependently impairs memory consolidation in open field habituation task in rats	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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relation.isAuthorOfPublication	43b53091-f5bf-4b46-b164-88d2a3670e2f
relation.isAuthorOfPublication.latestForDiscovery	dc3015b4-805d-4b6e-a49f-f2d73bb3c2b2