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Endogenous neurogenesis after intracerebral hemorrhage

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dc.contributor.authorOtero, L.
dc.contributor.authorZurita, M.
dc.contributor.authorBonilla, C.
dc.contributor.authorRico, M.A.
dc.contributor.authorAguayo, C.
dc.contributor.authorRodriguez, A.
dc.contributor.authorVaquero, J.
dc.date.accessioned2017-03-10T15:08:28Z
dc.date.available2017-03-10T15:08:28Z
dc.date.issued2012
dc.description.abstractCurrently, it is accepted that brain injury promotes endogenous neurogenesis in mammals, primarily in the subventricular zone (SVZ), and newborn cells can migrate to the injured area. We examined the pattern of endogenous neurogenesis in adult rats after intracerebral hemorrhage (ICH) that was caused by intrastrial administration of collagenase type IV. Our results showed that ICH induced strong endogenous neurogenesis between 72 hours and 7 days after injury, but that the majority of newborn cells did not survive longer than 3 weeks due to apoptosis-mediated cell death. Furthermore, endogenous neurogenesis remained into a small extent at least 1 year after ICH. Because of the growing interest in new strategies for brain regeneration, these data suggest endogenous neurogenesis and inhibiting apoptosis of newborn neuroblasts as potential strategies to improve the consequences of hemorrhagic stroke in humans.es
dc.formatapplication/pdfes
dc.identifier.citationHistology and Histopatholgy. Volume 27, number 3 (March), 2012
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/52400
dc.languageenges
dc.publisherF. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­a.es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectIntracerebral hemorrhagees
dc.subjectEndogenous neurogenesises
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - BiologĂ­aes
dc.titleEndogenous neurogenesis after intracerebral hemorrhagees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nÂş 3 (2012)