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Evaluating the link between BAFF system gene expression and acute rejection development in kidney transplantation

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dc.archivorevisadoOur work was possible thanks to support from Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness; Grant Number PI15/01370 and P19/01194 and co-funding from the European Union with the European Fund of Regional Development (FEDER) with the principle of “A manner to build Europe”.
dc.contributor.authorAlfaro, Rafael
dc.contributor.authorLlorente, Santiago
dc.contributor.authorJiménez Coll, Víctor
dc.contributor.authorMartínez Banaclocha, Helios
dc.contributor.authorGalián, José Antonio
dc.contributor.authorBotella, Carmen
dc.contributor.authorMoya Quiles, María Rosa
dc.contributor.authorMuro Pérez, Manuel
dc.contributor.authorPeña Moral, Jesús de la
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorMuro, Manuel
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-08T11:35:17Z
dc.date.available2024-07-08T11:35:17Z
dc.date.issued2022-07-07
dc.description© 2022 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Journal of Clinical Medicine (JCM). To access the final edited and published work see https://doi.org/10.3390/jcm11143956
dc.description.abstractB-cell activating factor (BAFF) system signaling is critical for B-cell homeostasis, effector functions, and tolerance maintenance in transplants, but it has not been studied in kidney transplant recipients (KTRs). The aim was to analyze the changes in BAFF system expression in KTRs with/without acute rejection (AR/NAR). The BAFF system expression was analyzed by qPCR in 40 KTRs. A meta-analysis of BAFF system expression and histological renal damage was identified by the Chronic Allograft Damage Index (CADI) and performed from the GEO database. Proliferation-inducing ligand (APRIL) expression increased at three- and six-months post-KT (p = 0.014 and p < 0.001). B-cell maturation antigen (BCMA) expression increased at six-months post-KT (p = 0.038). BAFF expression remained stable in NAR-KTRs, but was increased in CADI concerning the No-CADI group at one year (p = 0.008). BCMA expression increased in the CADI group at one- (p = 0.001) and six-years post-KT (p = 0.024). At three months, the transmembrane activator and calcium modulator interactor (TACI) gene significantly elevated KTRs with DSAs (donor-specific antibody; p = 0.034). KTRs with DSAs significantly increase the B-cell activating factor receptor (R-BAFF; p = 0.021) and TACI (p = 0.018) between pre- and three-month post-KT. Changes in the expression of the BAFF system increase during post-KTR in the development of AR and chronic allograft damage, and could be an important pathological tool to detect and prevent kidney graft outcomes.es
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dc.format.extent17es
dc.identifier.citationJournal Clinical Medicine 2022, 11(14), 3956
dc.identifier.doihttps://doi.org/10.3390/jcm11143956
dc.identifier.issnElectronic: 2077-0383
dc.identifier.urihttp://hdl.handle.net/10201/142932
dc.languageenges
dc.publisherMDPI
dc.relationOur work was possible thanks to support from Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness; Grant Number PI15/01370 and P19/01194 and co-funding from the European Union with the European Fund of Regional Development (FEDER) with the principle of “A manner to build Europe”.es
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/11/14/3956
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBAFF systemes
dc.subjectGene expressiones
dc.subjectKidney transplantes
dc.subjectForensic pathologyes
dc.subjectKidney transplantes
dc.titleEvaluating the link between BAFF system gene expression and acute rejection development in kidney transplantationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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