Publication:
Emerging histopathological parameters in the prognosis of oral squamous cell carcinomas

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dc.contributor.authorFreitas de Morais, Everton
dc.contributor.authorAlmangush, Alhadi
dc.contributor.authorSalo, Tuula
dc.contributor.authorSilva da, Sabrina Daniela
dc.contributor.authorKujan, Omar
dc.contributor.authorColetta, Ricardo D.
dc.date.accessioned2023-12-05T08:41:47Z
dc.date.available2023-12-05T08:41:47Z
dc.date.issued2024
dc.description.abstractOral squamous cell carcinoma (OSCC) is the most common oral malignancy, representing 90% of all malignant neoplasms in the head and neck region. Patients with this aggressive tumor have an overall 5year survival rate of approximately 50%, which drops to less than 30% when tumors are diagnosed at advanced clinical stages. Over decades, several studies provided high-level evidence of the impact of histopathological features on treatment guidelines and prognosis of OSCC. The 8th American Joint Committee on Cancer (AJCC) TNM staging system recognized the importance of depth of invasion to the T category and extranodal extension to the N category for OSCC. This review provides the current knowledge on emerging histopathological parameters identified as potential biomarkers for OSCC, such as depth of invasion, tumor thickness, the pattern of invasion, inflammatory profile, and tumor-stroma ratio, evaluating their clinical relevance on patient outcomes. Analysis, limitations, and potential biological mechanisms are highlighted and discussed. Assessing and reporting these markers are cost-effective and can be incorporated into daily practice.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 39, nº1 (2024)
dc.identifier.doihttps://doi.org/10.14670/HH-18-634
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/136403
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectOral canceres
dc.subjectHistopathological parameterses
dc.subjectPrognosises
dc.subjectDepth of invasiones
dc.subjectTumor thicknesses
dc.subjectPattern of invasiones
dc.subjectInflammatory profilees
dc.subjectTumor stroma ratioes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleEmerging histopathological parameters in the prognosis of oral squamous cell carcinomases
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.39, nº1 (2024)