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A clinicopathological study of eight cases presenting a biphasic structure: A distinct variant of pulmonary carcinoma

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dc.contributor.authorQiuyao Li
dc.contributor.authorJiwei Ma
dc.contributor.authorKun Yang
dc.contributor.authorXiaoyan Lin
dc.contributor.authorHuifeng Jiang
dc.contributor.authorYali Xu
dc.contributor.authorLin Song
dc.contributor.authorYu Zhang
dc.contributor.authorXiaoqian Liu
dc.contributor.authorZheng Mou
dc.contributor.authorWenjing Su
dc.contributor.authorHongyu Wang
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.date.accessioned2026-05-07T11:01:04Z
dc.date.available2026-05-07T11:01:04Z
dc.date.issued2026
dc.description.abstractBiphasic structures, which are composed of outer basal cells and inner glandular cells, are frequently indicative of salivary gland-type tumors or benign lesions, such as bronchial adenoma, within the lung. However, the occurrence of a biphasic structure in lung cancer is rarely reported and can lead to significant challenges and confusion in diagnosis, particularly in biopsy specimens. In our study, we collected eight lung epithelial tumors that presented with a distinct biphasic structure component and examined their clinicopathological characteristics. Histological examination revealed that the biphasic structure component, often intermingled with conventional squamous cell carcinoma or adeno carcinoma, was defined by basal cells encircling the glandular epithelium. Immunohistochemical analysis demonstrated a distinctive peripheral p40 staining pattern in the biphasic structure component. Genetic analysis identified driver mutations in seven out of eight patients, which are typically associated with conventional pulmonary adenocarcinomas, including EGFR L858R, EGFR 19-del, EGFR 20-ins, and KRAS mutations. The presence of biphasic structure components in these cases confirms a genuine form of lung cancer, likely representing a variant of lung adenocarcinoma. This study's findings enhance the understanding of lung cancer's morphological diversity and caution against prematurely dismissing the malignancy potential of pulmonary epithelial lesions based solely on the presence of basal cells, especially with biopsy specimens.
dc.formatapplication/pdf
dc.format.extent11
dc.identifier.doihttps://doi.org/10.14670/HH-25-004
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/230162
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiphasic structure
dc.subjectBasal cell
dc.subjectp40
dc.subjectSalivary gland like
dc.subjectLung cancer
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleA clinicopathological study of eight cases presenting a biphasic structure: A distinct variant of pulmonary carcinoma
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº5, (2026)