Publication: Lymphatic spread of mesenchymal renal tumor to metastatic parathymic lymph nodes in rat
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Date
2009
Authors
Rozsa, David ; Trencsenyi, Gyorgy ; Kertai, Pal ; Marian, Terez ; Nagy, Gabor ; Banfalvi, Gaspar
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Rat mesenchymal renal tumor cells (NeDe)
transplanted under the kidney capsule of F344 rats
resulted in metastases in the parathymic lymph nodes.
Tumor cells were isolated from these tumor-bearing
lymph nodes and 106 cells were implanted under the
kidney capsule. Tumor growth after this implantation
could be traced within six days. India ink was implanted
to prove that there is a connection between the lymphatic
vessels of the kidney capsule and the parathymic lymph
nodes. The distribution of the radioligand 18FDG in
different organs also provided evidence that the
parathymic lymph nodes are the primary sites of
metastatic tumor growth. Tumor growth was followed
after staining sections of biopsies of normal, tumorous
kidneys and parathymic lymph nodes embedded in
paraffin. The progression of tumor formation was seen
as a frontline between the healthy and tumor bearing
tissue. This demarcation line was sharp at the beginning
of the invasion and at the peripheral regions of the
tumor, while the central region infiltrated into the
healthy kidney tissue. The initial invasion gradually
turned to an infiltration resulting in the disruption of the
renal tissue, especially at the periphery. Accumulation of
lipids and flow of blood to the lymphatic vessels was
due to the lack of angiogenesis, leading to an increased
pressure of the interstitial fluid. Interstitial damage
ultimately led to the appearance of blood and the growth
of tumor cells in parathymic lymph nodes. The kidney
capsule-parathymic lymph node complex is proposed as
a suitable metastatic model for the isolated in vivo
examination of tumor development and for the analysis
of secondary tumors.
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