Publication: Interleukin 6 receptor (IL-6R) was an independent prognostic factor in cervical cancer
Authors
Luan, Shaohong ; An, Zhijie ; Bi, Shuna ; Chen, Long ; Fan, Jun
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-920
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info:eu-repo/semantics/article
Description
Abstract
IL-6 has been found to be associated with
poor response to chemoradiotherapy and poor overall
prognosis of patients with cervical cancer. However,
little is known about the clinicopathological significance
of IL-6 receptor (IL-6R) expression in the setting of
cervical cancer. To investigate the clinicopathological
meaning of IL-6R in cervical cancer, expression of IL6R was detected using immunohistochemistry in cervical
cancer tissue microarray composed of 98 cases of
cervical cancer and paired normal controls. As further
confirmation of expression trend, western-blotting was
conducted in another independent 36 pairs of cervical
cancer and matched normal controls. Subsequently, the
statistical correlation between IL-6R expression and
clinicopathological variables was analyzed, including
demographic, TNM stage, clinical grading and overall
prognosis. IL-6R expression was shown to be
remarkably associated with lymph node metastasis,
recurrence and overall prognosis. Moreover, only IL-6R
expression was observed to be an independent
prognostic factor among these variables that could
potentially influence the overall prognosis of patients
with cervical cancer. In conclusion, IL-6R was shown to
be an independent prognostic factor for patients with
cervical cancer.
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Citation
Histology and Histopathology, Vol.33, nÂş3, (2018)
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