Publication: lmmunocytochemical correlates of an extrapituitary adrenocortical regulation in man
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Date
1997
Authors
Heym, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Investigations reviewed in this article
provide cytochemical and functional support for a
significant involvement of extrapituitary factors in
human adrenocortical functions. Among these factors
neural messengers may play a crucial role in the
adrenocortical regulation, arising from specifically
coded postganglionic neurons with both, extrinsic and
intrinsic locations, as well as from chemically
characteristic afferent neurons. The close association of
varicose transmitter segments with steroid hormone
synthesizing cells and their occurrence at arteries and
sinusoid capillaries are indicative for both direct and
indirect regulatory mechanisms on cortical functions.
The immunohistochemical presence of neuropeptides
and cytokines in endocrine andlor immune cells of the
human adrenal medulla and cortex as well as specific
binding sites on steroidogenic cells indicate the
modulatory implication of additional short-paracrine-and
ultrashort-autocrine-feedback loops on cortical cell
proliferation and steroid metabolism. The summarized
data suggest that basa1 endocrine influence of the
hypothalamo-pituitary axis on adrenocortical growth and
functions in man is controlled by the nervous system that
also regulates local fine-tuning of human cortical
activity.
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