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High expression of the phosphoinositide 3-kinase p110γ isoform can predict poor prognosis of non-small cell lung cancer

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dc.contributor.authorJung, Ina
dc.contributor.authorLee, Hyoun Wook
dc.contributor.authorRoh, Mee Sook
dc.contributor.authorLee, Jae Seok
dc.contributor.authorKim, Kisu
dc.contributor.authorKim, Kyungeun
dc.contributor.authorKim, Tae Gyu
dc.contributor.authorNam, Hyun-Yeol
dc.date.accessioned2023-03-08T09:10:13Z
dc.date.available2023-03-08T09:10:13Z
dc.date.issued2022
dc.description.abstractThe protein p110γ is an isoform of the catalytic subunit of class I phosphoinositide 3-kinases (PI3Ks). PI3Ks are involved in the regulation of cell survival, growth, proliferation, and migration and have been implicated in the oncogenesis of various cancers. In this study, p110γ expression in non-small cell lung cancer (NSCLC) and its association with clinicopathological factors and patient survival were evaluated. A total of 230 NSCLC tumors were immunohistochemically stained for p110γ. Of these, 174 (75.7%) and 56 (24.3%) were placed in the low and high expression groups, respectively. The positive rate of p110γ was significantly higher in adenocarcinoma than in squamous cell carcinoma (p<0.001). Advanced stage NSCLCs showed higher p110γ expression than those at an early stage (p=0.002). Irrespective of the histological tumor type, the patients with high p110γ expression had significantly worse overall survival than those with low p110γ expression (p=0.004). p110γ expression was an independent poor prognostic factor in the multivariate analysis. Our results suggest that p110γ may be involved in the development and progression of NSCLC, and that p110γ has promising potential as a prognostic factor or novel therapeutic target for NSCLC.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology Vol. 37, nº12 (2022)
dc.identifier.doihttps://doi.org/10.14670/HH-18-480
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/129150
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectImmunohistochemistryes
dc.subjectNon-small cell lung canceres
dc.subjectPI3Kes
dc.subjectp110γes
dc.subjectPrognosises
dc.subjectTherapeutic targetes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHigh expression of the phosphoinositide 3-kinase p110γ isoform can predict poor prognosis of non-small cell lung canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.37,nº12 (2022)