Publication: Notch signaling in prostate cancer: refining a therapeutic opportunity
Authors
Su, Qingtai ; Xin, Li
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
10.14670/HH-11-685
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info:eu-repo/semantics/article
Description
Abstract
y. Notch is an evolutionarily conserved
signaling pathway that plays a critical role in specifying
cell fate and regulating tissue homeostasis and
carcinogenesis. Studies using organ cultures and
genetically engineered mouse models have demonstrated
that Notch signaling regulates prostate development and
homeostasis. However, the role of the Notch signaling
pathway in prostate cancer remains inconclusive. Many
published studies have documented consistent
deregulation of major Notch signaling components in
human prostate cancer cell lines, mouse models for
prostate cancers, and human prostate cancer specimens
at both the mRNA and the protein levels. However,
functional studies in human cancer cells by modulation
of Notch pathway elements suggest both tumor
suppressive and oncogenic roles of Notch. These
controversies may originate from our inadequate
understanding of the regulation of Notch signaling under
versatile genetic contexts, and reflect the multifaceted
and pleiotropic roles of Notch in regulating different
aspects of prostate cancer cell biology, such as
proliferation, metastasis, and chemo-resistance. Future
comprehensive studies using various mouse models for
prostate cancer may help clarify the role of Notch
signaling in prostate cancer and provide a solid basis for
determining whether and how Notch should be
employed as a therapeutic target for prostate cancer.
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Citation
Histology and Histopathology, vol.31, nÂş2, (2016)
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