Pericytes, a cell type contributing to autoimmunity and immune tolerance

Botía Sánchez, María; Molina, María Luisa; Aparicio, Pedro; Valdor Alonso, Rut

Publication:
Pericytes, a cell type contributing to autoimmunity and immune tolerance

dc.contributor.author	Botía Sánchez, María
dc.contributor.author	Molina, María Luisa
dc.contributor.author	Aparicio, Pedro
dc.contributor.author	Valdor Alonso, Rut
dc.contributor.department	Bioquímica y Biología Molecular B e Inmunología
dc.date.accessioned	2024-04-18T07:33:07Z
dc.date.available	2024-04-18T07:33:07Z
dc.date.issued	2023-06-16
dc.description	© 2023 Elsevier Inc.
dc.description.abstract	Pericytes have been, since their discovery, a very hard-to-define cell because of their unknown ontogeny and the lack of specific markers. As a consequence, several attempts to characterize both its molecular pattern and its metabolism have been carried out to describe the physiological role they play. Pericytes are located in the abluminal wall of small vessels and contribute to the maintenance of capillary tone and the regulation of oxygen flow to adjacent tissues, maintaining the homeostasis of the blood-brain barrier. Furthermore, they have been described as cells with immunological properties, being able to sense and secrete proinflammatory and antiinflammatory cytokines and to activate T cells, hence controlling the immune response. Interestingly, pericytes immune function might be modulated through molecular mechanisms such as chaperone-mediated autophagy, making them to convert from immunogenic to immunosuppressive cells contributing in autoimmunity and immune tolerance. The failure of the different pericytes functions which are implicated in the brain homeostasis is related with several pathologies associated to inflammation, including type 2 diabetes, multiple sclerosis, stroke, Alzheimer's disease, and cancer. In these scenarios, pericytes have always been proved as mediators of the pathology, which indicates that this barely-known type of cell might have a wide variety of unknown roles.
dc.embargo.terms	1-ene-2999
dc.format	application/pdf	es
dc.format.extent	31
dc.identifier.doi	https://doi.org/10.1016/B978-0-323-85841-0.00004-3
dc.identifier.isbn	Print: 978-0-323-85841-0
dc.identifier.isbn	Electrónico: 978-0-323-90071-3
dc.identifier.uri	http://hdl.handle.net/10201/140911
dc.language	eng	es
dc.publisher	Elsevier	es
dc.relation	Sin financiación externa a la Universidad.	es
dc.relation.ispartof	Translational Neuroimmunology, Vol. 7 Neuroinflammation. p.p.97-128
dc.rights	info:eu-repo/semantics/embargoedAccess	es
dc.subject	Pericytes
dc.subject	Immune response
dc.subject	Inflammation
dc.subject	Immunosuppressive
dc.subject	Chaperone-mediated autophagy
dc.subject	Blood-brain barrier
dc.title	Pericytes, a cell type contributing to autoimmunity and immune tolerance	es
dc.type	info:eu-repo/semantics/bookPart	es
dspace.entity.type	Publication	es
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