Publication: lnterferons and cell growth control
Authors
Kalvakolanu, D.V.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cytokines modulate cell growth,
differentiation, and immune defenses in the vertebrates.
Interferons (IFNs) are a unique class of cytokines that
stimulate antiviral, antitumor and antigen presentation by
inducing the expression of several cellular genes. Recent
studies have identified a novel gene regulatory pathway
activated by IFNs, which serves as a paradigm for most
cytokine signal transduction pathways. A number of
genes induced by IFNs participate in cell growth
regulation and apoptosis. These include novel tumor
suppressor genes. Although discovered as IFN-regulated
factors, deletions of these genes cause leukemias in
experimental models and in human patients. Genetic
approaches have identified several novel regulators of
apoptosis. Studies on the mechanism of action of these
growth regulatory molecules are not only useful in
identifying novel targets for the development of
therapeutics but also help understand the molecular basis
for loss of cell growth control and resistance to IFNs.
This review focuses on the functions and roles of IFN
regulated factors in cell growth control and mechanisms
of disruption of IFN action in cancer cells.
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