Publication: The Notch pathway, hair graying and pigment cell homeostasis
Authors
Schouwey, Karine ; Beermann, Friedrich
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The Notch signaling pathway is an essential
cell-cell interaction mechanism, which regulates
processes such as cell proliferation, cell fate decisions,
differentiation or stem cell maintenance. Pigmentation in
mammals is provided by melanocytes, which are derived
from the neural crest, and by the retinal pigment
epithelium (RPE), which is part of the optic cup and
hence orginates from neuroectoderm. The importance of
functional Notch signaling in melanocytes has been
unveiled recently. Here, the pathway is essential for the
maintenance of proper hair pigmentation. Deletion of
Notch1 and Notch2 or RBP-Jk in the melanocyte lineage
resulted in a gene dosage-dependent precocious hair
graying, due to the elimination of melanoblasts and
melanocyte stem cells. Expression data support the idea
that Notch signaling might equally be involved in
development of the RPE. Furthermore, recent analyses
indicate a possible role of Notch signaling in the
development of melanoma. In this review, we address
the essential role of Notch signaling in the regeneration
of the melanocyte population during hair follicle cycles,
and discuss data supporting the implication of this
signaling pathway in RPE development and melanoma.
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