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The plantaris tendon in association with mid-portion Achilles tendinosis – Tendinosis-like morphological features and presence of a non-neuronal cholinergic system

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dc.contributor.authorSpang, Christoph
dc.contributor.authorAlfredson, Hàkan
dc.contributor.authorFerguson, Mark
dc.contributor.authorRoos, Beverley
dc.contributor.authorBagge, Johan
dc.date.accessioned2018-05-11T13:58:43Z
dc.date.available2018-05-11T13:58:43Z
dc.date.issued2013
dc.description.abstractThe plantaris tendon is often neglected in morphological/clinical studies on the lower extremity. There is, however, clinical evidence that the plantaris tendon is involved in cases with Achilles midportion tendinopathy/tendinosis. It is nevertheless unclear if the plantaris tendon exhibits tendinosis-like features in this situation. We therefore investigated the plantaris tendon of patients with midportion Achilles tendinosis when the plantaris tendon was found to be located very close to or invaginated into the Achilles tendon, a situation which very often has been found to be the case. There was a very large number of tenocytes in the tendon tissue and the tenocytes showed abnormal and irregular appearances, exhibiting widened/rounded and wavy appearances, and were frequently lined up in rows. These features are characteristic features in Achilles tendinosis tendons. The tendon cells showed a distinct immunoreaction for the acetylcholine (ACh) -producing enzyme choline acetyltransferase (ChAT). Frequent fibroblasts were found in the loose connective tissue and these cells also showed a marked ChAT immunoreaction. The study shows that the plantaris tendon is morphologically affected in a similar way to the Achilles tendon in cases with midportion Achilles tendinosis and medial pain. The plantaris tendon may accordingly be a co-factor in these cases. The results also favour that there is a local ACh production both within the tendon tissue of the plantaris tendon and in the loose connective tissue. In conclusion, it is evident that plantaris tendons lying invaginated into or very close to the Achilles tendon in cases with midportion Achilles tendinosis show similar tendinosis features as previously shown for the Achilles tendon itself in these cases.es
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dc.format.extent10es
dc.identifier.citationHistology and histopathology, Vol. 28, n.º 5 (2013)
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/58322
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPlantaris tendones
dc.subjectAchilles tendones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThe plantaris tendon in association with mid-portion Achilles tendinosis – Tendinosis-like morphological features and presence of a non-neuronal cholinergic systemes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº 5 (2013)