Publication: Regulation and function of sphingosine kinase 2 in diseases
Authors
Song, Dan Dan ; Zhou, Jun Hao ; Sheng, Rui
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
publication.page.editor
publication.page.department
DOI
DOI: 10.14670/HH-11-939
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Sphingosine kinase functions to phosphorylate sphingosine to sphingosine 1-phosphate (S1P) to
keep balance in the metabolites of sphingolipids. There
are two isoforms of sphingosine kinase, sphingosine
kinase 1 (SphK1) and sphingosine kinase 2 (SphK2).
Although SphK1 and SphK2 share high sequence
similarity, SphK2 has distinct distribution, regulation
and function. SphK2 is involved in the pathological
processes of varieties of diseases including cancer,
neurodegenerative disorders, stroke, cardiovascular
diseases and inflammation. SphK2 may promote the
proliferation of cancer cells and the progression of
inflammation. The SphK2/S1P pathway is also involved
in the pathogenesis of neurodegenerative disorders and
stroke. S1P produced by SphK2 in the nucleus binds to
HDACs, which then inhibits histone acetylation and
regulates memory. The SphK2 pathway mediates platelet
aggregation, thrombosis, cardioprotection and helps to
ameliorate hepatic steatosis. This review focuses on the
recent advances in research on SphK2 regulation and its
potential roles in diseases, highlighting SphK2 may be a
novel therapeutic strategy for diseases.
publication.page.subject
Citation
Histology and Histopathology, Vol.33, nÂş5, (2018)
item.page.embargo
Ir a EstadĂsticas
Este Ătem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/