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Extracellular vesicles in seminal plasma: A safe and relevant tool to improve fertility in livestock?

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dc.contributor.authorHeriberto Rodriguez-Martinez
dc.contributor.authorRoca Aleu, Jordi
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-10-20T12:27:15Z
dc.date.available2025-10-20T12:27:15Z
dc.date.issued2022-09
dc.description.abstractSeminal plasma (SP) is not a pre-requisite for pregnancy. Yet, this heterogeneous, composite SP has proven relevant for fertility, as mediator for cell-to-cell communication between producing cells, spermatozoa and the female internal genital tract, regulating complex reproductive processes. Bearing hormones, proteins, cytokines as well as nuclei acids in nano-sized lipid bilayer seminal extracellular vesicles (sEVs), the SP concerts signaling to the female. Signals influence timing of ovulation, sperm transport and, particularly, enable the female immune system to balance her cryptic choice to engage into pregnancy or reject an eventual fertilization. This essay, focusing on livestock in general and pigs in particular, discusses the intrinsic roles of sEVs with regards to reproductive homeostasis, while binding and internalizing their cargo in spermatozoa and female tract epithelia to regulate their functional activity. Since prior studies had inconclusive results using bulk SP or single SP-contained free molecules, argumentation is hereby provided to increase the current incipient research on livestock sEVs, where fragile molecules relevant for fertility are shielded from degradation during handling. Seminal EVs isolated from SP can be used for andrological diagnosis and perhaps to select breeders with optimal fertility. Moreover, sEVs can be laboratory-uploaded with specific molecules or even engineered as lipid nanodroplets used as additives for extenders to improve fertility after artificial insemination (AI) or reproductive biotechnologies.
dc.formatapplication/pdf
dc.format.extent8
dc.identifier.citationAnim Reprod Sci . 2022 Sep:244:107051.
dc.identifier.doi10.1016/j.anireprosci.2022.107051
dc.identifier.eissn1873-2232
dc.identifier.urihttp://hdl.handle.net/10201/167689
dc.languageeng
dc.relationThe research of the authors was funded by the Research Council FORMAS, Stockholm (Grant 2019–00288) and Spanish Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033, PID2020–113493RB-I00), Madrid, Spain.
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378432022001300?via%3Dihub
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAntioxidants; Breeding additives; Cytokines; Diagnostics; Ejaculate; Extracellular vesicles, female genital tract; Fertility; Gene expression; Livestock; Pig; Proteome; Seminal plasma.
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleExtracellular vesicles in seminal plasma: A safe and relevant tool to improve fertility in livestock?
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
relation.isAuthorOfPublication032b17bf-c6a7-4745-a513-c02b384cc26c
relation.isAuthorOfPublication.latestForDiscovery032b17bf-c6a7-4745-a513-c02b384cc26c
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