Publication:
TWEAK/Fn14 signaling: a promising target in intervertebral disc degeneration

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dc.contributor.authorLiu, Yu-Ping
dc.contributor.authorYuan, Chong-Ming
dc.contributor.authorZhang, Shuai-Gong
dc.contributor.authorHao, Qing-Hai
dc.contributor.authorWang, Ming-Ming
dc.contributor.authorZhang, Zhong
dc.contributor.authorMeng, Qian
dc.contributor.authorLi, Ming
dc.contributor.authorHao, Yue-Dong
dc.date.accessioned2021-10-25T08:16:53Z
dc.date.available2021-10-25T08:16:53Z
dc.date.issued2016
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.citationHistology and Histopathology, Vol.31, nÂş9, (2016)
dc.identifier.doiDOI: 10.14670/HH-11-775
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/113267
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectTWEAKes
dc.subjectFn14es
dc.subjectTargetes
dc.subjectIntervertebral disces
dc.subjectDegenerationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleTWEAK/Fn14 signaling: a promising target in intervertebral disc degenerationes
dc.title.alternativeTumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a potent chemoattractant cytokine with various biological functions, such as stimulation of angiogenesis, induction of proinflammatory cytokines, regulation of cellular proliferation and apoptosis. Therefore, it has also been implicated in several pathological processes, from cancer to inflammatory diseases. Remarkably, TWEAK and its receptors, fibroblast growth factor inducible 14 (Fn14), are also present in intervertebral disc (IVD) tissue, where they play a role in the pathogenesis of IVD degeneration. The interaction of TWEAK with Fn14 is involved in physiological and pathological activities of IVD degeneration patients, which includes apoptosis of endplate chondrocytes, extracellular matrix degradation, reduction in proteoglycan synthesis and so on. The blockade of this interaction results in suppressing overproduction of proinflammatory factors and cell death in in vivo or in vitro experiments, suggesting that TWEAK/Fn14 signaling may be therapeutically relevant in IVD degeneration, and the targeting of TWEAK or Fn14 has been proposed as a potential therapeutic approach for autoimmune diseases such as Rheumatoid arthritis (RA). In this article, we discuss the biological features of TWEAK/Fn14 signaling and summarize recent advances in our understanding of the role of TWEAK/Fn14 signaling in the pathogenesis and treatment of IVD degeneration. We think that the blockade of TWEAK/Fn14 signaling may be a promising therapeutic strategy for IVD degeneration in the near future.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nÂş9 (2016)