Publication:
Interpretation of P16 expression as a marker of HPV in colorectal cancer

Simple item page
dc.contributor.authorHafez, Fatma Samy
dc.contributor.authorMeckawy, Ghada Refaat
dc.contributor.authorAlorabi, Mohamed
dc.contributor.authorShakweer, Marwa Mosaad
dc.date.accessioned2023-02-17T09:01:26Z
dc.date.available2023-02-17T09:01:26Z
dc.date.issued2022
dc.description.abstractBackground. Colorectal cancer is one of the most prevalent types of tumors worldwide. P16INK4a is a widely used immunohistochemical marker for high-risk HPV infection. The purpose of this study is to explore the relationship between P16 expression as an indicator of HPV infection and colorectal cancer in Egyptian patients, as well as its association with histopathological characteristics. Material and methods. The study was performed on 59 cases of colorectal carcinoma cases and 30 specimens of normal colonic mucosa. Results. p16 protein was detected in 22% (13 of 59) of patients with colorectal carcinoma. No evidence of P16 expression in all 30 cases of non-neoplastic colonic mucosa was found. More frequent expression of P16 was seen in distal carcinomas. Conclusion. our study demonstrated that P16 protein is expressed in a reasonable percent of colorectal carcinoma cases, suggesting a role of HPV in colorectal carcinogenesis. The present study highlights the role of p16 protein expression which is important in the pathogenesis in colorectal carcinoma, especially regarding distal tumorses
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and Histopathology Vol. 37, nº5 (2022)
dc.identifier.doihttps://doi.org/10.14670/HH-18-439
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/128548
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectP16 proteines
dc.subjectColorectal carcinomaes
dc.subjectImmunohistochemistryes
dc.subjectDistal tumores
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleInterpretation of P16 expression as a marker of HPV in colorectal canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Hafez-37-475-481-2022.pdf
Size:
1.49 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.37, nº5 (2022)