Publication: Autocrine endothelial regulation in brain stem vessels of newborn piglets
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Date
1999
Authors
Lange, D. ; Funa, K. ; Ishisaki, K. ; Bauer, R. ; Wollina, Uwe
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Vasoactive intestinal peptide (VIP) is known
as a potent regulator for the development of the central
nervous system (CNS). The neonatal period of brain
development is characterised by rapid cellular
proliferation in parallel with neuronal differentiation and
angiogenesis. We examined the expression of native VIP
and the VIP receptor-associated protein by immunohistochemistry
as well as the expression of VIP mRNA
by in situ hybridisation in the brain stem of newborn
piglets. We found both the mRNA and the protein of VIP
as well as the VIP receptor-associated protein in
endothelial cells of veins, arteries and capillaries in the
marginal zone of brain stem tissue sections, especially in
pons and mesencephalon, as well as in pia1 vessels. The
coexpression of native VIP, VIP mRNA and the VIP
receptor-associated protein within the endothelium
suggests the presence of an autocrine loop, which has
been detected so far only in neuroblastoma cells. This
expression pattern gives evidence to the immaturity of
endothelial cells at birth and the presence of an adaptive
response in the VIP-regulated system during the change
from intra- to extrauterine life.
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