Publication:
Expression of prostate specific membrane antigen (PSMA) in prostatic adenocarcinoma and prostatic intraepithelial neoplasia

Simple item page
dc.contributor.authorMarchal, C.es
dc.contributor.authorRedondo, M.es
dc.contributor.authorPadilla, M.
dc.contributor.authorCaballero, J.
dc.contributor.authorRodrigo, I.
dc.contributor.authorGarcía, J.
dc.contributor.authorQuian, J.
dc.contributor.authorBoswick, D.G.
dc.date.accessioned2011-06-08T09:09:06Z
dc.date.available2011-06-08T09:09:06Z
dc.date.issued2004
dc.description.abstractThe prostatic membrane antigen (PSMA) is a protein that is expressed in the prostatic epithelium. We studied the expression of PSMA in a series of 55 patients with different stages of prostate cancer and we compared the PSMA staining in prostate cancer cells, in high-grade prostatic intraepithelial neoplasia (PIN) and in histologically benign prostatic epithelium for the same specimen. For this purpose archival paraffin-embedded specimens were studied by immunohistochemistry with a monoclonal antibody 7E11-C5.3 against PSMA using the streptavidin-biotin method. The mean percentage of PSMA immunoreactivity was 56.67% in prostate cancer (CaP) cells, and 48.6% in PIN cells, which was significantly higher than benign-appearing prostatic epithelium (5.72%) (for each pair, p<0.001). PSMA expression was greater in CaP with a higher Gleason score (p=0.01), but no relationship was found with serum PSA value. We conclude that PSMA overexpression is detected in high-grade PIN and is associated with a higher Gleason score of prostate cancer. It is a potential marker for studying carcinogenesis and progression of prostate cancer.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21601
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectProstatic carcinomaes
dc.subjectPSMAes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.6 - Patología del sistema genitourinarioes
dc.titleExpression of prostate specific membrane antigen (PSMA) in prostatic adenocarcinoma and prostatic intraepithelial neoplasiaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Expression of prostate specific.pdf
Size:
1.07 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.19, nº 3 (2004)