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A subset of solitary fibrous tumors express nuclear PAX8 and PAX2: a potential diagnostic pitfall

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dc.contributor.authorMcDaniel, Andrew S.
dc.contributor.authorPalanisamy, Nallasivam
dc.contributor.authorSmith, Steven C.
dc.contributor.authorRobinson, Dan R.
dc.contributor.authorWu, Yi-Mi
dc.contributor.authorChinnaiyan, Arul M.
dc.contributor.authorMcHugh, Jonathan B.
dc.contributor.authorGreenson, Joel K.
dc.contributor.authorKunju, Lakshmi P.
dc.date.accessioned2021-04-13T10:49:07Z
dc.date.available2021-04-13T10:49:07Z
dc.date.issued2016
dc.description.abstractSolitary fibrous tumor (SFT), a mesenchymal neoplasm with widespread anatomic distribution, can be diagnostically challenging in limited samples. We recently encountered an aspirate of a pancreatic mass, incorrectly interpreted as metastatic renal cell carcinoma based on strong PAX8 expression by immunohistochemistry (IHC). After resection, morphologic features with additional IHC (CD34 positivity) correctly identified this lesion as a SFT. PAX8 and PAX2 are commonly used as renal tumor markers; however, no series has investigated PAX8 or PAX2 expression in SFT. IHC for PAX8 and PAX2 was performed on 41 SFTs (biopsy and resections) from varying sites. Eight were histologically malignant and eight were recurrences of previous resections. PAX8 staining was observed at least focally in 26.8% (11 of 41) SFT cases; additionally, PAX2 was positive in 12.2% (5 of 41 cases) of SFTs. For PAX8 and PAX2 positive cases 45.6% and 40%, respectively, showed diffuse expression. No correlation was found between PAX8/PAX2 positivity and age, tumor size, site, malignancy, or recurrence. In conclusion, a substantial minority of SFTs express PAX8 and PAX2 via IHC. This presents a diagnostic pitfall when evaluating possible metastases from the kidney, particularly when primary tumors show sarcomatoid or spindle cell morphologies.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, vol.31, nÂş2, (2016)
dc.identifier.doi10.14670/HH-11-670
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/106441
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSolitary fibrous tumorses
dc.subjectPAX8es
dc.subjectPAX2es
dc.subjectImmunohistochemistryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleA subset of solitary fibrous tumors express nuclear PAX8 and PAX2: a potential diagnostic pitfalles
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nÂş2 (2016)