Publication: Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated
transport, in normal and neoplastic human tissue
Authors
Marazuela, M. ; Alonso, M. A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Polarized transport of lipids and proteins to
the apical and basolateral membrane subdomains is
essential for the functioning of epithelial cells. Apical
transport is mediated by a direct route from the Golgi
and an indirect route, referred to as transcytosis,
involving the transport of the protein to the basolateral
membrane followed by its internalization and subsequent
transcellular transport to the apical subdomain. MAL
and MAL2 have been demonstrated to be essential
components of the machinery for the direct and indirect
routes, respectively. Herein, we review the range of
expression of MAL and MAL2 in normal human tissue
and compare it with that of neoplastic tissue. Our
analysis provides insight into the potential use of MALand
MAL2-mediated pathways in many types of
epithelial cells as well as in nonepithelial cells. In
addition, the specific alterations in MAL and/or MAL2
expression observed in specific types of carcinoma
provides a basis to understand the loss of the polarized
phenotype that frequently accompanies the neoplastic
transformation process. This points out potential
applications of MAL and MAL2 as markers for tumor
characterization.
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