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An overview of chemically induced rodent models for sporadic colorectal cancer: Histopathological and translational perspectives

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dc.contributor.authorSarmiento Machado, Luis Manuel
dc.contributor.authorMarchesan Rodrigues, Maria Aparecida
dc.contributor.authorRibeiro Romualdo, Guilherme
dc.contributor.authorBarbisan, Luís Fernando
dc.date.accessioned2024-05-21T09:28:45Z
dc.date.available2024-05-21T09:28:45Z
dc.date.issued2024
dc.description.abstractGlobally, colorectal cancer (CRC) is one of the most frequently diagnosed human gastrointestinal neoplasia and the second leading cause of cancer-related death in both men and women. Despite considerable efforts currently devoted to the study of the biology and treatment of CRC, patient prognosis and survival are still poor. Sporadic CRC is a complex multistep disease and usually emerges in the setting of lifestyle and dietary changes mainly observed in industrialized countries with high human development index (HDI) (westernized style). The molecular pathogenesis of sporadic CRC presents genetic heterogeneity with APC, RAS, PIK3CA, TGFBR, SMAD4, and TP53 mutations usually detected during the progression of this malignancy. The establishment of sporadic CRC models has become essential for both basic and translational research to improve our understanding of the pathophysiology, unravel new molecular drivers, and preventive/ therapeutic improvement of this malignancy. Chemically induced rodent models of sporadic CRC recapitulate most key morphological and genetic/epigenetic events observed during the promotion and progression of this malignancy, establishing effective diagnostic and prevention strategies to be translated into clinical practice. The present review gathers the main features of the state-of-the-art evidence on chemically induced rodent models, widely applied for translational modelling of sporadic CRC with a specific focus on histopathology and prevention perspectives. Our narrative review reinforces the persistent value of these bioassays and encourages the use of multimodel strategies for further investigationses
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dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 39, nº6 (2024)
dc.identifier.doihttps://doi.org/10.14670/HH-18-692
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/141712
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSporadic colorectal canceres
dc.subjectChemically induced rodent modelses
dc.subjectPreneoplastic and neoplastic lesionses
dc.subjectChemoprevention and preventive strategieses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAn overview of chemically induced rodent models for sporadic colorectal cancer: Histopathological and translational perspectiveses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.39, nº6 (2024)