Publication:
Molecular roles of MAP kinases and FADD phosphorylation in prostate cancer

Thumbnail Image
Files
Molecular roles of MAP kinases and FADD phosphorylation in prostate cancer.pdf(1.94 MB)
Date
2006
relationships.isAuthorOfPublication
relationships.isSecondaryAuthorOf
relationships.isDirectorOf
Authors
Shimada, K. ; Nakamura, M. ; Ishida, E. ; Konishi, N.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Mitogen activated protein (MAP) kinases are well known serine threonine kinases that modulate gene expression, mitosis, cell proliferation and programmed cell death or ‘apoptosis’ in response to various stresses. Extracellular stress regulated kinase (ERK), c-jun NH2 terminal kinase and p38 are major members of the MAP kinases, and there is now a body of evidence of their involvement in genesis or sensitivity to chemotherapy of human prostate cancers. In this review, we focus on the molecular roles of MAP kinases and their pathological correlations, with particular attention to novel downstream signals through phosphorylation of the Fasassociated death domain protein that effectively regulates not only apoptosis but also the cell cycle in prostate neoplastic cells.
publication.page.subject
MAP kinase , FADD phosphorylation
Citation
URI
http://hdl.handle.net/10201/22638
item.page.embargo
Collections
Histology and histopathology Vol.21, nº 4 (2006)
Ir a Estadísticas