Publication: Sequential pattern of nerve-muscle contacts in the small intestine of developing human fetus. An ultrastructural and immunohistochemical study
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Date
1996
Authors
Fekete, Eva ; Benedeczky, I. ; Timmermans, J.P. ; Resch, B.A. ; Scheuermann, D.V.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The developing enteric nervous system of the
human fetus has been studied by means of electron
microscopy and neuron-specific enolase immunocytochemistry
between the 10th and 26th week of gestation,
with special reference to the development of nervemuscle
contacts. In the 10th week of gestation the
circular muscle layer is formed, followed by the
appearance of a primitive myenteric plexus, and the
longitudinal smooth muscle layer in the 12th week of
gestation. Adherens-type junctions between the smooth
muscle cells and the elements of the myenteric plexus,
interdigitation of nerve and muscle processes, and also
contacts without any morphological specialization are
frequent until the 18th week, when the mechanical
points of attachment are relocated from the circular to
the longitudinal muscle layer. By this time the
developing myenteric plexus becomes ensheathed by
non-neuronal cells, disrupting the direct contacts
between smooth muscle cells and the primary strands of
the myenteric plexus. The possible functional
significance of these changing nerve-muscle contacts is
discussed in the present paper.
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