Publication: An up-date on newly discovered
immunohistochemical biomarkers for the
diagnosis of human testicular germ cell tumors
Authors
Chieffi, Paolo ; Chieffi, Sergio
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Although testicular germ cell tumors
(TGCTs) are relatively uncommon, they are particularly
important, as they tend to affect children and young men,
the most common tumor being in males aged from 20 to
40 years, and the incidence has been increasing in the
last years.
TGCTs comprise two major histologic groups:
seminomas and non-seminomas germ cell tumors
(NSGCTs). NSGCTs can be further divided into
embryonal, carcinoma, Teratoma, yolk sac tumor, and
choriocarcinoma. Seminomas and NSGCTs present
significant differences in clinical features, therapy, and
prognosis, and both show characteristics of the
Primordial Germ Cells (PGCs).
For proper diagnosis of the different histological
subgroups, immunohistochemistry is required using
different molecular markers, such as Aurora B, GPR30,
Nek2, HMGA1, HMGA2, and others, and they could
represent useful novel molecular targets for
antineoplastic strategies. More insight into the
pathogenesis of TGCTs is likely to contribute not only to
better treatment of these tumors but also to a better
understanding of stem cells and oncogenesis.
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Citation
Histology and Histopathology, vol. 29, nº 8, (2014)
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