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Site differences of Toll-like receptor expression in the mucous epithelium of rat small intestine

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dc.contributor.authorMantani, Youhei
dc.contributor.authorKamezaki, Aosa
dc.contributor.authorUdayanga, Kankanam Gamage Sanath
dc.contributor.authorTakahara, Ei-ichirou
dc.contributor.authorQi, Wang-Mei
dc.contributor.authorKawano, Junichi
dc.contributor.authorYokoyama, Toshifumi
dc.contributor.authorHoshi, Nobuhiko
dc.contributor.authorKitagawa, Hiroshi
dc.date.accessioned2016-04-29T14:46:33Z
dc.date.available2016-04-29T14:46:33Z
dc.date.issued2011
dc.description.abstractToll-like receptors (TLRs) are known to recognize pathogen-associated molecular patterns and might function as receptors to detect microbes. In this study, the distribution of TLR-2, -4 and -9 were immunohistochemically investigated in the rat small intestine. As a result, TLR-2 was detected in the striated borders of villous columnar epithelial cells throughout the small intestine, except for the apices of a small number of intestinal villi. TLR-4 and -9 were detected in the striated borders of the villous columnar epithelial cells only in the duodenum. TLR-4-immunopositive minute granules were found in the apical cytoplasms of epithelial cells, subepithelial spaces and blood capillary lumina. TLR-2 and -4 were detected in the striated borders of undifferentiated epithelial cells and in the luminal substances of the intestinal crypts throughout the small intestine, but TLR-9 was not detected in the crypts throughout the small intestine. Only TLR-4 was detected in the secretory granules of Paneth cells in both the jejunal and ileal intestinal crypts. These findings suggest that duodenal TLRs might monitor indigenous bacteria proliferation in the upper alimentary tract, that TLR-2 might also monitor the proliferation of colonized indigenous bacteria throughout the small intestine, that the lack of TLR-2 at the villous apices might contribute to the settlement of indigenous bacteria, and that TLR-2 and -4 are secreted from intestinal crypts.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/49445
dc.languageenges
dc.publisherF. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología.es
dc.relation.ispartofHistology and histopathology, Vol. 26, nº10 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectEpitheliumes
dc.subjectImmunohistochemistryes
dc.subject.other61 - Medicinaes
dc.titleSite differences of Toll-like receptor expression in the mucous epithelium of rat small intestinees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26,nº10 (2011)