Publication: Effects of low dose of tibolone on steroid receptors and Bcl-2 on the postmenopausal endometrium
Authors
Reis, Benedito Fabiano ; Lima, Sonia Maria Rolim R. ; Silva, Gustavo Maximiliano D. ; Francisco, Antonio Marcos C. ; Barbosa, Lyliana Coutinho R. ; Archangelo, Silvania C. Vieira ; Grande, Rogerio M.
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-706
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info:eu-repo/semantics/article
Description
Abstract
Objective: A prospective randomized
controlled trial was conducted to evaluate the effect of
low dose of tibolone on the histology, expression of
estrogen (ER) and progesterone receptors (PR) and Bcl2 protein, in endometrium of postmenopausal women.
Method: Forty postmenopausal women consented to
treatment and were allocated into two groups of
20 women: Group 1 (Control) without hormone
replacement therapy (HRT); Group 2 (Tibolone)
treatment at the dose of 1.25 mg/day of oral tibolone
administered for a 24-week period. The effect on the
endometrium was assessed by histology and the
apoptosis marker Bcl-2. The immunoexpression of ER
and PR were also measured.
Results: Tibolone group showed higher expression
of ER, PR and Bcl-2 protein in glandular epithelium and
stroma compared to control group.
Conclusion: Tibolone in a daily dose of 1.25 mg
during 24 weeks demonstrated endometrial action that
resulted in low proliferation and was shown to lead to
atrophic endometrium. It had favorable effects on the
postmenopausal endometrium due to its higher
immunoexpression of PR and Bcl-2 protein in
endometrial glandular epithelium, thereby creating a
balance between pro-apoptotic and anti-apoptotic actions.
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Citation
Histology and histopathology: Vol.31, nÂş6 (2016)
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