Publication: Distribution of CD105 and CD166 positive cells in the proximal epiphysis of developing rat humerus
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Date
2010
Authors
Ozbey, Ozlem ; Sahin, Zeliha ; Acar, Nuray ; Ustunel, Ismail
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The expression of cell surface receptors,
CD105 and CD166, are characteristic of mesenchymal
stem cells in cartilage. However, there is limited data
regarding their immunolocalization in the cartilage of
developing rat epiphysis. The purpose of this study was
to determine the presence of CD105 and CD 166
positive cells in the proximal epiphysis of developing rat
humerus and specify their zonal distribution with age.
The tissues of rat humerus were taken on embryonic day
15 (E15), embryonic day 19 (E19), postnatal day 10
(PN10), postnatal day 20 (PN20) and adult rats and
studied for the immunolocalization of CD105 and
CD166. Our results showed that CD105 and CD166
positive cells were scattered in early stages of
development of humerus epiphysis. For E15, only the
hypertrophic zone was positive, whereas for E19 almost
all zones of the epiphysis were positively stained for
these markers. For PN10 and PN20, the CD105 and
CD166 positive cells were mainly localized on the
surface of the articular cartilage. In adult articular
cartilage the CD105 and CD166 positive cells were
localized in the superficial and transitional zones and in
the upper regions of the deep zone. Our study provides
evidence that in the developing cartilage tissue the
localization of CD105 and CD166 positive cells is both
dynamic and stage dependent, which may imply the
existence of stem cell-like cells in cartilage from an
early age to adult.
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