Publication: Organelle dynamics and membrane trafficking in apoptosis and autophagy
Loading...
Date
2010
Authors
Cheng, Jade P.X. ; Lane, Jon D.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The accurate control of cell death is a vital
aspect of development in metazoans and plays crucial
roles in the prevention of disease. Apoptosis is the main
form of regulated cell death in multicellular organisms,
although there are other contributory pathways. During
apoptosis, mammalian cells undergo dramatic changes in
organelle structure ad organisation that define the
apoptotic execution phase. Although the roles of
apoptotic protease machinery (the caspases) in these
rearrangements are quite well understood, the purpose of
organelle disruption during cell death is not yet entirely
appreciated. Indeed, recent evidence implicates caspase
targeting of organellar proteins and subsequent organelle
disruption upstream of apoptotic execution proper,
suggesting the existence of pathways linking organelle
damage to cell death. In this review, we describe the
changes to the endomembrane system that are inherent
during the apoptotic execution phase, and examine the
evidence for endomembrane-mediated pathways towards
apoptotic execution. We also discuss aspects of the
molecular control of autophagy - an important
contributor to a cell’s response to stress, and a membrane
trafficking process whose regulation is linked to the
apoptotic machinery at multiple levels.
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.