Publication: The morphological changes of exocrine pancreas in chronic pancreatitis
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Date
1999
Authors
Ashizawa, N. ; Niigaki, M. ; Hamamoto, N. ; Kaji, T. ; Katsube, T. ; Sato, S. ; Endoh, H. ; Hidaka, K. ; Watanabe, M. ; Kinoshita, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The following changes were found by either
light or electron microscopic observation of the pancreas
in spontaneously developed chronic pancreatitis models
(WBNIKob rats, spontaneously hypertensive rats, and
rats with common bile-pancreatic duct stones) and in
experimental models of chronic pancreatitis (alcoholic
pancreatitis, ischemic pancreatitis, and obstructive
pancreatitis): 1) the units of lobules, which were
constituted by acinar cell deletion, ductular proliferation,
and fibrosis; and 2) tortuous or helical ductal channels of
pancreatic ducts with periductal fibrosis, which had
many crater-like depressions and very long cilia in their
inner surface. These are considered to be the results of
obstructive pancreatitis, which are caused by the
reactions of defensive factors against the increase of
pancreatic duct pressure, including the apoptosis of
acinar cells, the hyperplasia and hypertrophy of duct
cells, a tighter junctional complex of duct cells, and
periductal fibrosis.
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